Root Cause of Crohn’s Disease

Crohn’s disease is a chronic inflammatory disorder that can affect any part of the gastrointestinal tract. The Root Cause of Crohn’s Disease is unknown but it typically affects the ileum. Crohn’s disease may lead to ulceration and stenosis of the bowel. Crohn’s disease is a chronic digestive condition where inflammation causes a person’s intestines to become thick and narrow, leading to problems digesting food. This inflammation usually starts in the small intestine and then progresses to other areas of the digestive tract. It is one of the most common diseases for people in their thirties and forties. It is estimated that 1 out of every 150 people in North America has Crohn’s Disease. A physician named Dr Burrill Crohn identified this disease in 1932 and named it after his name. Often, Crohn’s patients experience bouts of diarrhea, abdominal pain, fever, weight loss, and malnutrition.

The cause of Crohn’s disease has been difficult to determine because not all people with Crohn’s disease have the same symptoms or characteristics. On average, those who suffer from Crohn’s disease will see symptoms appear between 15 and 20 years old. Some believe that Crohn’s is caused by a bacterium called Mycobacterium avium subspecies paratuberculosis (MAP). Others believe it is caused by immune system malfunction, smoking, Other possible causes are genetics and smoking cigarettes, obesity, and certain foods.

There are many theories that have been suggested to be the Root Cause of Crohn’s Disease. Some of them are listed below:

1- Immune System Causes Crohn’s Disease:

Crohn’s disease can be difficult to manage and is a type of inflammatory bowel disease. It is believed that the immune system creates the inflammation that leads to diseases such as Crohn’s. There are many different causes of Crohn’s, but they all have one thing in common: they start with an overactive immune system. Causes of Crohn’s disease are unknown. But it is thought that the immune system plays a role in the development of inflammation. Scientists have found that people who develop Crohn’s disease often have mutations in the NOD2 gene that regulate the immune system.

One possible explanation for Crohn’s disease is exaggerated immune responses to gut bacteria. Crohn’s disease, which causes inflammation of the lining of the digestive tract, is an autoimmune disorder. The immune system is meant to protect us from germs that cause infection. In some people, the immune system mistakenly identifies parts of our own intestinal tissue as foreign invaders. The body then produces antibodies against its own tissues, leading to devastating consequences. Peanut Butter helps to improve immunity.

2- Genetic Disposition Causes Crohn’s Disease:

Crohn’s disease can be caused by a number of factors, but genetic predisposition is the likely cause in most cases. Geneticists have long been trying to find a correlation between genetics and Crohn’s Disease. It has been found that the gene that causes the development of this chronic inflammatory bowel disorder is located on chromosome 6p21.2 and is inherited from one parent with Crohn’s Disease. Israeli scientists and at the Broad Institute of MIT and Harvard have found a genetic mutation in Crohn’s patients. They believe this genetic mutation may be an underlying cause of the disease.

In 2017, Dr Craig D. Robinson and fellow colleagues authored an article published in The Journal of Clinical Gastroenterology. The article examines the genetic disposition to Crohn’s disease, with a focus on the NOD2/CARD15 gene. Researchers found that nationwide, nearly half of all patients with Crohn’s disease had mutations in their genes, while only 6% of the general population had identical mutations. In a new study, researchers analyzed data from more than 800,000 people. They found that people who had a specific variation in one of their genes were 50% more likely to develop Crohn’s disease later in life.

3- Environmental Factors Causes Crohn’s Disease:

Crohn’s Disease is a chronic inflammatory bowel disease that can affect any region of the gastrointestinal tract. The exact cause of Crohn’s Disease is unknown, but it may be connected with environmental factors. After experiencing an increase in Crohn’s disease in the past few decades, scientists are now trying to identify environmental factors that can contribute to the onset of this gastrointestinal inflammation. Genes may also be the risk of developing Crohn’s disease. It is also possible for these gene-associated changes to have occurred as a result of environmental factors. Crohn’s disease is an autoimmune disorder. It means it can be triggered by environmental factors like bacteria, viruses, exposure to radiation, and smoking.

4- Smoking Causes Crohn’s Disease:

Crohn’s disease is a chronic intestinal disorder that can be debilitating, and it often produces an assortment of symptoms that vary from person to person. One environmental factor that has been associated with Crohn’s is heavy exposure to cigarette smoke during childhood. Children who live with a smoker will ingest on average four times more nicotine and eighty-four percent more tar than children who do not live with smokers. Crohn’s disease has been associated with smoking but the mechanism for this association remains unclear. The use of nicotine in tobacco may induce chronic intestinal inflammation due to its direct effects on the mucosal immune system.


In conclusion, according to the Crohn’s and Colitis Foundation of America (CCFA), it affects 750,000 people in North America. Crohn’s disease is a painful and debilitating disorder. It can affect the entire gastrointestinal system and lead to life-threatening complications. Patients should always consult with a gastroenterologist if they suspect they or their loved ones may have this illness. Treatment for Crohn’s Disease can be difficult and may take years to find a cure. Whatever the root cause of Crohn’s disease may be, it is important for patients to be aware of the symptoms and seek medical help early to prevent any damage.

There is currently no cure for Crohn’s Disease, but there are treatments to help manage symptoms.

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